Blood Clots in Ulcerative Colitis; AI Tool for MASH; Stomach Cancer Screening?
Gastroenterology > General Gastroenterology
— News and commentary from the world of gastroenterology and hepatology
December 11, 2025 - 2 min read
A real-world analysis from Japan suggests that patients with ulcerative colitis (UC) who are on advanced therapies may have a lower risk of venous thromboembolism and cardiovascular events when treated with vedolizumab (Entyvio) compared with TNF inhibitors. The study also hints that 5-aminosalicylic acid could offer some protective effect against thrombosis (Inflammatory Bowel Diseases).
Among first-degree relatives of people with Crohn’s disease (CD), calprotectin measurements helped identify family members who already have presymptomatic CD and could be ideal candidates for prevention trials (Gut).
The FDA has qualified the first artificial intelligence (AI) tool to assist pathologists in evaluating disease activity during drug trials for metabolic dysfunction-associated steatohepatitis (MASH).
In a randomized trial, adding a gastric electrical stimulation implant to pyloroplasty produced greater symptom relief and shorter hospital stays for gastroparesis patients (JAMA Network Open).
GLP-1–based therapies may offer potential benefits related to disease in UC patients with a history of pouchitis, according to a small study (Inflammatory Bowel Diseases).
A nationwide Swedish study found that opioid use was higher in adults with UC in the two years before diagnosis and remained elevated for up to five years afterward (Inflammatory Bowel Diseases).
Evidence indicates Black and Hispanic individuals with inflammatory bowel disease may experience disease-related post-traumatic stress disorder symptoms (Inflammatory Bowel Diseases).
A liquid biopsy using a panel of six cell-free and exosome-based circulating biomarkers demonstrated high specificity and sensitivity for detecting colorectal cancers, which could aid early screening (Gastroenterology).
In England, a preoperative dietary intervention for overweight patients undergoing curative-intent colorectal cancer resection was associated with weight loss and some improvements in postoperative symptoms (JAMA Network Open).
A case-control analysis found no link between angiogenesis inhibitors used for metastatic colorectal cancer and the risk of arterial dissections or aneurysms (JAMA Network Open).
Could colorectal cancer screening in the United States be cost-effective? (Clinical Gastroenterology and Hepatology)
Researchers in Clinical Gastroenterology and Hepatology described new subtypes of functional dysphagia (FD) characterized by striated muscle contractility and by different patterns of distal esophageal distensibility: FD with reduced esophageal distension and FD with preserved distension.
Approximately one-quarter of patients with primary sclerosing cholangitis report moderate to severe pruritus, a symptom associated with greater disease severity (Hepatology).
Lower diastolic blood pressure in women correlates with an increased risk of ischemic colitis, according to an analysis of the Women’s Health Initiative cohort (American Journal of Gastroenterology).
A case report documents a patient with treatment-refractory, multiorgan IgG4-related disease involving the hepatobiliary system achieving remission after CAR T-cell therapy (Journal of Hepatology).
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